Modulation of the high-order chromatin structure by Polycomb complexes

Modulation of the high-order chromatin structure by Polycomb complexes

Blog Article

The multi-subunit Polycomb Repressive Complex (PRC) 1 and 2 act, either independently or synergistically, to maintain and enforce a repressive state of the target chromatin, thereby regulating the processes of cell lineage specification and organismal development.In Cough Drops recent years, deep sequencing-based and imaging-based technologies, especially those tailored for mapping three-dimensional (3D) chromatin organization and structure, have allowed a better understanding of the PRC complex-mediated long-range chromatin contacts and DNA looping.In this review, we review current advances as for how Polycomb complexes function to modulate and help define the high-order chromatin structure and topology, highlighting Cooktop Burner Gasket the multi-faceted roles of Polycomb proteins in gene and genome regulation.